ABSTRACT
Superficial vein thrombosis (SVT) is a very common disease even though its incidence
has never been assessed properly. Until recently, the literature on this topic has
been relatively poor, old, and with numerous methodologic drawbacks, probably because
this disease was considered benign and trivial. However, the recent recognition of
a frequent association with concomitant venous thromboembolism (VTE) (deep vein thrombosis
[DVT] and pulmonary embolism [PE]) and the risk of subsequent VTE complications in
patients with isolated SVT has revived interest and has encouraged new clinical research.
SVT and VTE share many common predisposing risk factors. Even if varicose veins represent
the main cause of SVT, several underlying conditions (e.g., malignancy, thrombophilia,
autoimmune diseases) should be sought, especially in idiopathic, migrant, or recurrent
SVT of nonvaricose vein patients. The diagnosis is made in a clinical setting but
ultrasonography is useful to identify concomitant asymptomatic DVT. Many medical and
surgical treatments have been suggested to relieve local symptoms and signs, prevent
recurrences, and limit the VTE risk of SVT, but the evidence coming from the limited
number of prospective randomized studies does not allow strong recommendations on
the optimal treatment of SVT.
KEYWORDS
Superficial vein thrombosis - superficial thrombophlebitis - Duplex ultrasonography
- hypercoagulable states - venous thrombosis
REFERENCES
- 1
Coon W W, Willis P W, Keller J B.
Venous thromboembolism and other venous disease in the Tecumseh community health study.
Circulation.
1973;
48
839-846
- 2
Hafner C, Cranley J J, Krause R, Strasser E S.
A method of managing superficial thrombophlebitis.
Surgery.
1964;
55
201-206
- 3
Husni E A, Williams A.
Superficial thrombophlebitis of the lower limbs.
Surgery.
1982;
91
70-74
- 4
Plate G, Eklof B, Jensen R, Ohlin P.
Deep vein thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of
the long saphenous vein.
Acta Chir Scand.
1985;
151
241-244
- 5
Bergqvist D, Jaroszewski H.
Deep vein thrombosis in patients with superficial thrombophlebitis of the leg.
BMJ.
1986;
292
658-659
- 6
Skillman J J, Kent K C, Porter D H, Kim D.
Simultaneous occurrence of superficial and deep thrombophlebitis in the lower extremity.
J Vasc Surg.
1990;
11
818-823
- 7
Lutter K, Kerr T, Roedersheimer R et al..
Superficial thrombophlebitis diagnosed by duplex scanning.
Surgery.
1991;
110
42-46
- 8
Pulliam C W, Barr S L, Ewing A B.
Venous duplex scanning in the diagnosis and treatment of progressive superficial thrombophlebitis.
Ann Vasc Surg.
1991;
5
190-195
- 9
Lohr J M, McDevitt D T, Lutter K S, Roedersheimer L R, Sampson M G.
Operative management of greater saphenous thrombophlebitis involving the saphenofemoral
junction.
Am J Surg.
1992;
164
269-275
- 10
Jorgensen J O, Hanel K C, Morgan A M, Hunt J M.
The incidence of deep vein thrombosis in patients with superficial thrombophlebitis
of the lower limbs.
J Vasc Surg.
1993;
18
70-73
- 11
Ascer E, Lorensen E, Pollina R M, Gennaro M.
Preliminary results of a nonoperative approach to saphenofemoral junction thrombophlebitis.
J Vasc Surg.
1995;
22
616-621
- 12
Somjen G M, Donlan J, Hrse J et al..
Duplex ultrasound examination of acutely painful and swollen leg.
Dermatol Surg.
1996;
22
383-387
- 13
Bounameaux H, Reber-Wasem M A.
Superficial thrombophlebitis and deep vein thrombosis. A controversial association.
Arch Intern Med.
1997;
157
1822-1824
- 14
Blumenberg R M, Barton E, Gelfand M L et al..
Occult deep vein thrombosis complicating superficial thrombophlebitis.
J Vasc Surg.
1998;
27
338-343
- 15
Belcaro G, Nicolaides A N, Errichi B M et al..
Superficial thrombophlebitis of the legs: a randomized, controlled, follow-up study.
Angiology.
1999;
50
523-529
- 16
Unno N, Mitsuoka H, Uchiyama T et al..
Superficial thrombophlebitis of the lower limbs in patients with varicose veins.
Surg Today.
2002;
32
397-401
- 17
Ascher E, Hanson J, Salles-Cuncha S, Hingorani A.
Lesser saphenous vein thrombophlebitis: its natural history and implications for management.
Vasc Endovascular Surg.
2003;
37
421-427
- 18
Verlato F, Zucchetta P, Prandoni P et al..
Unexpected high rate incidence of pulmonary embolism in patients with superficial
thrombophlebitis of the thigh.
J Vasc Surg.
1999;
30
1113-1115
- 19
Sover E R, Brammer H M, Rowedder A M.
Thrombosis of the proximal greater saphenous vein: ultrasonographic diagnosis and
clinical significance.
J Ultrasound Med.
1997;
16
113-116
- 20
Chengelis D L, Bendick P J, Glover J L, Brown O W, Ranval T J.
Progression of superficial venous thrombosis to deep vein thrombosis.
J Vasc Surg.
1996;
24
745-749
- 21
The STENOX Study Group .
A randomized double-blind comparison of low molecular weight heparin, non steroidal
anti-inflammatory agent and placebo in the treatment of superficial vein thrombosis.
Arch Intern Med.
2003;
163
1657-1663
- 22
Decousus H, Epinat M, Guillot K et al..
Superficial vein thrombosis risk factors, diagnosis and treatment.
Curr Opin Pulm Med.
2003;
9
393-397
- 23
Leon L, Giannoukas A D, Dodd D, Chan P, Labropoulos N.
Clinical significance of superficial vein thrombosis.
Eur J Vasc Endovasc Surg.
2005;
29
10-17
- 24
Edwards E A.
Thrombophlebitis of varicose veins.
Surg Gynecol Obstet.
1938;
66
236-245
- 25
Guex J J.
Thrombotic complications of varicose veins.
Dermatol Surg.
1996;
22
378-382
- 26
Leon L R, Lapropoulos N.
Superficial vein thrombosis and hypercoagulable states: the evidence.
Perspect Vasc Surg Endovasc Ther.
2005;
17
43-46
- 27
Samlaska C P, James W D.
Superficial thrombophlebitis. 1. Primary hypercoagulable states.
J Am Acad Dermatol.
1990;
22
975-989
- 28
Samlaska C P, James W D.
Superficial thrombophlebitis. 2. Secondary hypercoagulable states.
J Am Acad Dermatol.
1990;
23
1-18
- 29
Hanson J N, Ascher E, de Pippo P et al..
Saphenous vein thrombophlebitis (SVT): a deceptively benign disease.
J Vasc Surg.
1998;
27
677-680
- 30
De Moerloose P, Wutschert R, Heinzmann M et al..
Superficial vein thrombosis of lower limbs: influence of factor V Leiden, factor II
G21210A and overweight.
Thromb Haemost.
1998;
80
239-241
- 31
Martinelli I, Cattaneo M, Taioli E et al..
Genetic risk factors for superficial vein thrombosis.
Thromb Haemost.
1999;
82
1215-1217
- 32
Subramaniam P, Van Doornum S.
Superficial thrombophlebitis: underlying hypercoagulable states.
Aust NZ J Surg.
1999;
69
461-463
- 33
De Godoy J M, Braile D M.
Protein S deficiency in repetitive superficial thrombophlebitis.
Clin Appl Thromb Hemost.
2003;
9
61-62
- 34
De Godoy J M, Batigalia F, Braile D M.
Superficial thrombophlebitis and anticardiolipin antibodies report of association.
Angiology.
2001;
52
127-129
- 35
McColl M D, Ramsay J E, Tait R C et al..
Superficial vein thrombosis: incidence in association with pregnancy and prevalence
of thrombophilic defects.
Thromb Haemost.
1998;
79
741-742
- 36
James K V, Lohr J M, Deshmukh R M, Cranley J J.
Venous thrombotic complications of pregnancy.
Cardiovasc Surg.
1996;
4
777-782
- 37
Vandenbroucke J P, Rosing J, Bloemenkamp K WM et al..
Oral contraceptives and the risk of venous thrombosis.
N Engl J Med.
2001;
344
1527-1535
- 38
Rosendaal F R, Helmerhohorst F M, Vandenbroucke J P.
Oral contraceptives, hormone replacement therapy and thrombosis.
Thromb Haemost.
2001;
86
112-123
- 39
Sagdic K, Ozer Z G, Saba D et al..
Venous lesions in Behçet's disease.
Eur J Vasc Endovasc Surg.
1996;
11
437-440
- 40
Aqel M B, Olin J W.
Thromboangiitis obliterans (Buerger's disease).
Vasc Med.
1997;
2
61-66
- 41
Ikeda M, Kambayashi J, Iwamoto S et al..
Hemostasis activation during sclerotherapy of lower extremity varices.
Thromb Res.
1996;
82
87-95
- 42
Brook I, Frazier E.
Aerobic and anaerobic microbiology of superficial suppurative thrombophlebitis.
Arch Surg.
1996;
131
95-97
- 43
Gorty S, Patton-Adkins J, DaLanno M et al..
Superficial venous thrombosis of the lower extremities: analysis of risk factors,
and recurrence and role of anticoagulation.
Vasc Med.
2004;
9
1-6
- 44
Heit J A, Silverstein M D, Mohr D N et al..
Risk factors for deep vein thrombosis and pulmonary embolism: a population-based controlled
study.
Arch Intern Med.
2000;
160
809-815
- 45
Tosetto A, Frezzato M, Rodeghiero F.
Prevalence and risk factors of non-fatal venous thromboemblism in the active population
of the VITA project.
J Thromb Haemost.
2003;
1
1724-1729
- 46
Schonauer V, Kyrle P A, Weltermann A et al..
Superficial thrombophlebitis and risk for recurrent venous thromboembolism.
J Vasc Surg.
2003;
37
834-838
- 47
Yucel E K, Egglin T K, Waltman A C.
Extension of saphenous thrombophlebitis into the femoral vein: demonstration by color
flow compression sonography.
J Ultrasound Med.
1992;
11
285-287
- 48
Siragusa S.
Should superficial vein thrombosis of the proximal greater vein be objectively evaluated
in emergency wards?.
Thromb Haemost.
2000;
83
962-963
- 49
Gorski G, Noszczyc W, Kostewicz W et al..
Progress of local symptoms of superficial vein thrombosis vs. duplex findings.
Vasa.
2004;
33
219-225
- 50
Quenet S, Laporte S, Decousus H et al..
Factors predictive of venous thrombotic complications in patients with isolated superficial-vein
thrombosis.
J Vasc Surg.
2003;
38
944-949
- 51
Messmore H L, Bishop M, Wehrmacher W H.
Acute venous thrombosis. Therapeutic choices for superficial and deep veins.
Postgrad Med.
1991;
89
73-77
- 52
Neher J O, Safranek S, Greenwald J L.
What is the best therapy for superficial thrombophlebitis?.
J Fam Pract.
2004;
53
583-585
- 53
De Maeseneer M G.
Superficial thrombophlebitis of the lower limbs: practical recommendations for diagnosis
and treatment.
Acta Chir Belg.
2005;
105
145-147
- 54
Gjöres J E.
Surgical therapy of ascending thrombophlebitis in the saphenous system.
Angiology.
1962;
13
241-243
- 55
Williams R, Zollinger R.
Surgical treatment of superficial thrombophlebitis.
Surg Gynecol Obstet.
1964;
118
745-747
- 56
Krause U, Kock H J, Kroger K, Albrecht K, Rudofsky G.
Prevention of deep venous thrombosis associated with superficial thrombophlebitis
of the leg by early saphenous vein ligation.
Vasa.
1998;
27
34-38
- 57
Beatty J, Fitridge R, Benveniste G, Greenstein G.
Acute superficial venous thrombophlebitis: does emergency surgery has a role?.
Int Angiol.
2002;
21
93-95
- 58
Titon J P, Auger D, Grange P et al..
Traitement curatif des thromboses veineuses superficielles par nadroparine calcique.
Recherche posologique et comparaison à un anti-inflammatoire non stéroidien.
Ann Cardiol Angeiol (Paris).
1994;
43
160-166
- 59
Kalodiki E, Nicolaides A N.
Superficial thrombophlebitis and low-molecular-weight heparins.
Angiology.
2002;
53
659-663
- 60
Sullivan V, Denk P M, Sonnad S S et al..
Ligation versus anticoagulation treatment of above-knee superficial thrombophlebitis
not involving the deep venous system.
J Am Coll Surg.
2001;
193
556-562
- 61
Metha P P, Sagar S, Kakkar V V.
Treatment of superficial thrombophlebitis: a randomised, double-blind trial of heparinoid
cream.
BMJ.
1975;
3
614-616
- 62
Bagliani A, Montalbetti L.
Topical treatment of thrombophlebitis with feprazone and benzydamine. Controlled clinical
study.
Minerva Med.
1976;
67
880-884
- 63
Bergqvist D, Brunkwall J, Jensen N, Persson N H.
Treatment of superficial thrombophlebitis. A comparative trial between placebo, Hirudoid
cream and piroxicam gel.
Ann Chir Gynaecol.
1990;
79
92-96
- 64
Ferrari E, Pratesi C, Scaricabarozzi I.
A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis.
Drugs.
1993;
46
197-199
- 65
Vilardell M, Sabat D, Arnaiz J A et al..
Topical heparin for the treatment of acute superficial phlebitis secondary to indwelling
intravenous catheter. A double blind, randomised, placebo-controlled trial.
Eur J Clin Pharmacol.
1999;
54
917-921
- 66
Becherucci A, Bagilet D, Marenghini J et al..
Effect of topical and oral diclofenac on superficial thrombophlebitis caused by intravenous
infusion.
Med Clin (Barc).
2000;
114
371-373
- 67
Marchiori A, Verlato F, Sabbion P et al..
High versus low doses of unfractionated heparin for the treatment of superficial thrombophlebitis
of the leg. A prospective, controlled, randomized study.
Haematologica.
2002;
87
523-527
- 68
Lozano F, Almazan A.
Low-molecular-weight heparin versus saphenofemoral disconnection for the treatment
of above-knee greater saphenous thrombophlebitis: a prospective study.
Vasc Endovascular Surg.
2003;
37
415-420
- 69
The Vesalio Investigators Group .
High vs. low doses of low-molecular-weight heparin for the treatment of superficial
vein thrombosis of the legs: a double-blind, randomised trial.
J Thromb Haemost.
2005;
3
1149-1151
- 70
Decousus H, Leizorovicz A.
Superficial thrombophlebitis of the legs: still a lot to learn.
J Thromb Haemost.
2005;
3
1149-1151
- 71
Büller H, Agnelli G, Hull R D et al..
Antithrombotic therapy for venous thromboembolic disease. The 7th ACCP Conference
on Antithrombotic and Thrombolytic Therapy.
Chest.
2004;
126
401S-428S
Antonio MarchioniM.D.
Department of Emergency Medicine, S. Anthony Hospital
35128 Padua, Italy
Email: antonio.marchioni@unipd.it